Vitalef 100 is drug product erectile function is produced by pharmaceutical company Korea Prime Pharm is the licensed medical Visa circulation, the VN-20542-17 with the main active ingredient is Sildenaf an active substance very popular in treating the problem of erectile dysfunction, premature ejaculation of men.
Composition of Vitalef 100
Each film-coated tablets contains:
Pharmaceutical substances: Sildenaf citrate equivalent to Sildenaf 100mg
Excipients: Microcrystalline cellulose, anhydrous dibasic calcium phosphate, copovidone, croscarmellose Sodium, stearyl sodium fumarate, opadry Blue 85F20775.
Pharmacodynamics of Vitalef 100
Sildenaf selective inhibitor of the phosphodiesterase type 5(PDE5), increases the concentration of guanosin monophosphat round (CGMP), which causes vasodilation and increases blood flow.
Effects cause erectile penis: Sildenaf cause a decrease in mild or moderate systolic blood pressure(8 – 10mmHg) and diastolic(4-6mmHg), this effect is most pronounced 1 hour after drink, and return to the basic status after 4 hours .
This effect is due to the impact of varicose veins and peripheral arteries of sildenaf not dose dependent (25-200mg) or ages, and rarely causes it blood pressure can stand.
Pharmacokinetics of Vitalef 100
Sildenaf citrate is rapidly absorbed after ki drink, the bioavailability reached 40%. Metabolized primarily through the liver(cytocrom P450 3A4) the metabolite has activity similar sildenaf. The user coordinate with the inhibitor sytocrom P450 3A4( such as erythromy, ketocona, itracona) as well as the inhibitor of non-specific cytocrom P450(such as cimetidine) increase the concentration of sildenaf in the blood plasma.
Absorption and distribution:
Sildenaf quickly absorbed when used. Peak concentrations in plasma are reached within 30 – 120 minutes(average 60 minutes) after ingestion. If served with meals that are high in flour, then the absorption rate will decrease. The volume of distribution at steady state Vss=105 L, distribution into the tissues in the body.
Sildenaf and the main metabolite N – desmethyl attached to plasma proteins is about 90%, does not depend on the total amount of drug in the blood.
Metabolized and excreted:
Sildenaf is metabolized primarily via hepatic CYP 3A4(major) and CYO 2C9(women). The main metabolite is N-desmethyl sildenaf and this quality also continues to be transformed. Both sildenaf and high cuyển ive have half move waste except for about 4 hours.
Sildenaf excreted as metabolites mainly in the faeces(80%) and a smaller portion via urine (13%).
The drug is indicated for the treatment cases erectile dysfunction when can’t achieve or maintain an erection of the penis when done sex in men, mature. To the drug to be effective, need to have sexual stimulation.
Highlights of Vitalef 100
Produced by the pharmaceutical company Korea Prime Pharm Korean origin. One of the Asian countries, have high quality medicinal products, cosmetics top.
Effects fast and effective after only 30 minutes of use and prolonged duration of effect up to 4-5h. Help you comfortable relations, although there is “much agreement”.
The use of Vitalef 100
Makes erection, increases the excitement and feeling of sex, helping to treat the problems men have
Recovery of physiological functions and of the stronger sex
Treatment status on the physiological diseases like premature ejaculation and no erection
Dosage and administration
Adults: the recommended Dose is 50mg, drink about 1 hour before sex.
Based on efficacy and tolerability, the dose may be increased to 100mg or reduced to 25mg. Only 1 in 24 hours, so drink away meal to be able to absorb best.
Elderly: No dose adjustment in people ≥ 65 years of age.
Patients with hepatic impairment, renal impairment require dose adjustment according to patient’s condition.
Hypersensitivity to the components of VITALEF
Women and children
Patients with atherosclerotic vascular spread, the coronary artery disease, cerebrovascular
The patient lost vision in 1 eye
Storage: in sealed container, avoid moisture, avoid light, temperature below 30 C.
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